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SYNCE

SYNCE sports supplement source list

Here you'll find all the scientific studies per formula on which we base our ingredient selections, dosages, and OZ score . Everything is verifiable and will be updated as soon as new and strong evidence indicates otherwise.

INTRODUCTION

  • This formula is based on more than 106 studies used to learn how specific ingredients work, what potential dosages and ingredients can mean acutely or mechanistically, and which effects and mechanisms matter for an effective workout and the post-training period; for example, keeping the chance of a crash or an unpleasant experience as low as possible.

L-CITRULLINE, MALATE (MALIC ACID) & L-CITRULLINE MALATE

  • https://pubmed.ncbi.nlm.nih.gov/34134794/ Valaei, Kosar et al. “Effects of L-citrulline supplementation on nitric oxide and antioxidant markers after high-intensity interval exercise in young men: a randomized controlled trial.” The British journal of nutrition, 1-23. 17 Jun. 2021, doi:10.1017/S0007114521002178
  • https://pubmed.ncbi.nlm.nih.gov/28940638/ Gonzales, Joaquin U et al. “Does l-citrulline supplementation improve exercise blood flow in older adults?.” Experimental physiology vol. 102,12 (2017): 1661-1671. doi:10.1113/EP086587
  • https://pubmed.ncbi.nlm.nih.gov/21908948/ Takeda, Kohei et al. “Effects of citrulline supplementation on fatigue and exercise performance in mice.” Journal of nutritional science and vitaminology vol. 57,3 (2011): 246-50. doi:10.3177/jnsv.57.246
  • https://pubmed.ncbi.nlm.nih.gov/28664349/ Kiyici, Fatih et al. “The Effect of Citrulline/Malate on Blood Lactate Levels in Intensive Exercise.” Biochemical genetics vol. 55,5-6 (2017): 387-394. doi:10.1007/s10528-017-9807-8
  • https://pubmed.ncbi.nlm.nih.gov/26808848/ Cunniffe, Brian et al. “Acute Citrulline-Malate Supplementation and High-Intensity Cycling Performance.” Journal of strength and conditioning research vol. 30,9 (2016): 2638-47. doi:10.1519/JSC.0000000000001338
  • https://pubmed.ncbi.nlm.nih.gov/39408204/ Devrim-Lanpir, Asli et al. “Effects of Acute Citrulline Malate Supplementation on CrossFit® Exercise Performance: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study.” Nutrients vol. 16,19 3235. 24 Sep. 2024, doi:10.3390/nu16193235
  • https://pubmed.ncbi.nlm.nih.gov/12145119/ Bendahan, D et al. “Citrulline/malate promotes aerobic energy production in human exercising muscle.” British journal of sports medicine vol. 36,4 (2002): 282-9. doi:10.1136/bjsm.36.4.282
  • https://pubmed.ncbi.nlm.nih.gov/26658899/ Glenn, Jordan M et al. “Acute citrulline malate supplementation improves upper- and lower-body submaximal weightlifting exercise performance in resistance-trained females.” European journal of nutrition vol. 56,2 (2017): 775-784. doi:10.1007/s00394-015-1124-6
  • https://pubmed.ncbi.nlm.nih.gov/34010809/ Vårvik, Fredrik Tonstad et al. “Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis.” International journal of sport nutrition and exercise metabolism vol. 31,4 (2021): 350-358. doi:10.1123/ijsnem.2020-0295
  • https://pubmed.ncbi.nlm.nih.gov/20386132/ Pérez-Guisado, Joaquín, and Philip M Jakeman. “Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.” Journal of strength and conditioning research vol. 24,5 (2010): 1215-22. doi:10.1519/JSC.0b013e3181cb28e0
  • https://pubmed.ncbi.nlm.nih.gov/33308806/ Rhim, Hye Chang et al. “Effect of citrulline on post-exercise rating of perceived exertion, muscle soreness, and blood lactate levels: A systematic review and meta-analysis.” Journal of sport and health science vol. 9,6 (2020): 553-561. doi:10.1016/j.jshs.2020.02.003
  • https://pubmed.ncbi.nlm.nih.gov/25674699/ Wax, Benjamin et al. “Effects of Supplemental Citrulline-Malate Ingestion on Blood Lactate, Cardiovascular Dynamics, and Resistance Exercise Performance in Trained Males.” Journal of dietary supplements vol. 13,3 (2016): 269-82. doi:10.3109/19390211.2015.1008615
  • https://pubmed.ncbi.nlm.nih.gov/27017895/ Glenn, Jordan M et al. “Acute citrulline-malate supplementation improves maximal strength and anaerobic power in female, masters athletes tennis players.” European journal of sport science vol. 16,8 (2016): 1095-103. doi:10.1080/17461391.2016.1158321
  • https://pubmed.ncbi.nlm.nih.gov/10793157/ Anderson, J E. “A role for nitric oxide in muscle repair: nitric oxide-mediated activation of muscle satellite cells.” Molecular biology of the cell vol. 11,5 (2000): 1859-74. doi:10.1091/mbc.11.5.1859
  • https://pubmed.ncbi.nlm.nih.gov/29553034/ Campos, Helton O et al. “Nitrate supplementation improves physical performance specifically in non-athletes during prolonged open-ended tests: a systematic review and meta-analysis.” The British journal of nutrition vol. 119,6 (2018): 636-657. doi:10.1017/S0007114518000132
  • https://pubmed.ncbi.nlm.nih.gov/27749691/ Figueroa, Arturo et al. “Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance.” Current opinion in clinical nutrition and metabolic care vol. 20,1 (2017): 92-98. doi:10.1097/MCO.0000000000000340
  • https://pubmed.ncbi.nlm.nih.gov/17662090/ Schwedhelm, Edzard et al. “Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.” British journal of clinical pharmacology vol. 65,1 (2008): 51-9. doi:10.1111/j.1365-2125.2007.02990.x
  • https://pubmed.ncbi.nlm.nih.gov/38874989/ Faria, Vinicius S, and Brendan Egan. “Effects of 3 days of citrulline malate supplementation on short-duration repeated sprint running performance in male team sport athletes.” European journal of sport science vol. 24,6 (2024): 758-765. doi:10.1002/ejsc.12090
  • https://pubmed.ncbi.nlm.nih.gov/34319940/ Gills, Joshua L et al. “Acute Citrulline-Malate Supplementation Increases Total Work in Short Lower-Body Isokinetic Tasks for Recreationally Active Females During Menstruation.” Journal of strength and conditioning research vol. 37,6 (2023): 1225-1230. doi:10.1519/JSC.0000000000004095
  • https://pubmed.ncbi.nlm.nih.gov/16368075/ McKenna MC, Waagepetersen HS, Schousboe A, Sonnewald U. “Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools.” Biochem Pharmacol. 2006;71(4):399-407. doi:10.1016/j.bcp.2005.10.011
  • https://pubmed.ncbi.nlm.nih.gov/3491492/ Schantz PG, Sjöberg B, Svedenhag J. “Malate-aspartate and alpha-glycerophosphate shuttle enzyme levels in human skeletal muscle: methodological considerations and effect of endurance training.” Acta Physiol Scand. 1986;128(3):397-407. doi:10.1111/j.1748-1716.1986.tb07993.x

BETA-ALANINE

  • https://pubmed.ncbi.nlm.nih.gov/27377257/ Berti Zanella, Priscila et al. “Effects of beta-alanine supplementation on performance and muscle fatigue in athletes and non-athletes of different sports: a systematic review.” The Journal of sports medicine and physical fitness vol. 57,9 (2017): 1132-1141. doi:10.23736/S0022-4707.16.06582-8
  • https://pubmed.ncbi.nlm.nih.gov/29905904/ Bassinello, Diogo et al. “Beta-alanine supplementation improves isometric, but not isotonic or isokinetic strength endurance in recreationally strength-trained young men.” Amino acids vol. 51,1 (2019): 27-37. doi:10.1007/s00726-018-2593-8
  • https://pubmed.ncbi.nlm.nih.gov/23630039/ Ducker, Kagan J et al. “Effect of beta-alanine supplementation on 800-m running performance.” International journal of sport nutrition and exercise metabolism vol. 23,6 (2013): 554-61. doi:10.1123/ijsnem.23.6.554
  • https://pubmed.ncbi.nlm.nih.gov/23630052/ Howe, Samuel T et al. “The effect of beta-alanine supplementation on isokinetic force and cycling performance in highly trained cyclists.” International journal of sport nutrition and exercise metabolism vol. 23,6 (2013): 562-70. doi:10.1123/ijsnem.23.6.562
  • https://pubmed.ncbi.nlm.nih.gov/17136505/ Stout, J R et al. “Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women.” Amino acids vol. 32,3 (2007): 381-6. doi:10.1007/s00726-006-0474-z
  • https://pubmed.ncbi.nlm.nih.gov/17194255/ Stout, Jeffrey R et al. “Effects of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold.” Journal of strength and conditioning research vol. 20,4 (2006): 928-31. doi:10.1519/R-19655.1
  • https://pubmed.ncbi.nlm.nih.gov/39032921/ Georgiou, George D et al. “Effect of Beta-Alanine Supplementation on Maximal Intensity Exercise in Trained Young Male Individuals: A Systematic Review and Meta-Analysis.” International journal of sport nutrition and exercise metabolism vol. 34,6 397-412. 19 Jul. 2024, doi:10.1123/ijsnem.2024-0027
  • https://pubmed.ncbi.nlm.nih.gov/25894892/ Carpentier, Alain et al. “β-Alanine supplementation slightly enhances repeated plyometric performance after high-intensity training in humans.” Amino acids vol. 47,7 (2015): 1479-83. doi:10.1007/s00726-015-1981-6
  • https://pubmed.ncbi.nlm.nih.gov/29246277/ Varanoske, Alyssa N et al. “β-Alanine supplementation elevates intramuscular carnosine content and attenuates fatigue in men and women similarly but does not change muscle l-histidine content.” Nutrition research vol. 48 (2017): 16-25. doi:10.1016/j.nutres.2017.10.002
  • https://pubmed.ncbi.nlm.nih.gov/27797728/ Saunders, Bryan et al. “β-alanine supplementation to improve exercise capacity and performance: a systematic review and meta-analysis.” British journal of sports medicine vol. 51,8 (2017): 658-669. doi:10.1136/bjsports-2016-096396
  • https://pubmed.ncbi.nlm.nih.gov/34069981/ Sas-Nowosielski, Krzysztof et al. “Beta-Alanine Supplementation and Sport Climbing Performance.” International journal of environmental research and public health vol. 18,10 5370. 18 May. 2021, doi:10.3390/ijerph18105370
  • https://pubmed.ncbi.nlm.nih.gov/31622158/ Milioni, Fabio et al. “Effect of β-alanine supplementation during high-intensity interval training on repeated sprint ability performance and neuromuscular fatigue.” Journal of applied physiology vol. 127,6 (2019): 1599-1610. doi:10.1152/japplphysiol.00321.2019
  • https://pubmed.ncbi.nlm.nih.gov/28121265/ Claus, Gabriel Machado et al. “Beta-Alanine Supplementation Improves Throwing Velocities in Repeated sprint ability and 200-m Swimming Performance in Young Water Polo Players.” Pediatric exercise science vol. 29,2 (2017): 203-212. doi:10.1123/pes.2016-0176
  • https://pubmed.ncbi.nlm.nih.gov/18992136/ Stout, Jeffrey R et al. “The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 Years): a double-blind randomized study.” Journal of the International Society of Sports Nutrition vol. 5 21. 7 Nov. 2008, doi:10.1186/1550-2783-5-21
  • https://pubmed.ncbi.nlm.nih.gov/17690198/ Derave, Wim et al. “beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters.” Journal of applied physiology vol. 103,5 (2007): 1736-43. doi:10.1152/japplphysiol.00397.2007
  • https://pubmed.ncbi.nlm.nih.gov/18175046/ Kendrick, Iain P et al. “The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition.” Amino acids vol. 34,4 (2008): 547-54. doi:10.1007/s00726-007-0008-3
  • https://pubmed.ncbi.nlm.nih.gov/20962010/ Overgaard K, Højfeldt GW, Nielsen OB. “Effects of acidification and increased extracellular potassium on dynamic muscle contractions in isolated rat muscles.” J Physiol. 2010;588(Pt 24):5065-76. doi:10.1113/jphysiol.2010.195727
  • https://pubmed.ncbi.nlm.nih.gov/20479615/ Artioli GG, Gualano B, Smith A, Stout J, Lancha AH Jr. “Role of beta-alanine supplementation on muscle carnosine and exercise performance.” Med Sci Sports Exerc. 2010;42(6):1162-73. doi:10.1249/MSS.0b013e3181c74e38
  • https://pubmed.ncbi.nlm.nih.gov/31083045/ Matthews JJ, Artioli GG, Turner MD, Sale C. “The Physiological Roles of Carnosine and β-Alanine in Exercising Human Skeletal Muscle.” Med Sci Sports Exerc. 2019;51(10):2098-2108. doi:10.1249/MSS.0000000000002033
  • https://pubmed.ncbi.nlm.nih.gov/22174397/ Dutka TL et al. “Effects of carnosine on contractile apparatus Ca²⁺ sensitivity and sarcoplasmic reticulum Ca²⁺ release in human skeletal muscle fibers.” J Appl Physiol. 2012;112(5):728-36. doi:10.1152/japplphysiol.01331.2011

GLYCEROL

  • https://pubmed.ncbi.nlm.nih.gov/23075560/ van Rosendal, S P, and J S Coombes. “Glycerol use in hyperhydration and rehydration: scientific update.” Medicine and sport science vol. 59 (2012): 104-112. doi:10.1159/000341959
  • https://pubmed.ncbi.nlm.nih.gov/11591882/ Anderson, M J et al. “Effect of glycerol-induced hyperhydration on thermoregulation and metabolism during exercise in heat.” International journal of sport nutrition and exercise metabolism vol. 11,3 (2001): 315-33. doi:10.1123/ijsnem.11.3.315
  • https://pubmed.ncbi.nlm.nih.gov/17962713/ Goulet, Eric D B et al. “A meta-analysis of the effects of glycerol-induced hyperhydration on fluid retention and endurance performance.” International journal of sport nutrition and exercise metabolism vol. 17,4 (2007): 391-410. doi:10.1123/ijsnem.17.4.391
  • https://pubmed.ncbi.nlm.nih.gov/23487412/ Patlar, Suleyman et al. “The effect of glycerol supplements on aerobic and anaerobic performance of athletes and sedentary subjects.” Journal of human kinetics vol. 34 (2012): 69-79. doi:10.2478/v10078-012-0065-x
  • https://pubmed.ncbi.nlm.nih.gov/8775573/ Montner, P et al. “Pre-exercise glycerol hydration improves cycling endurance time.” International journal of sports medicine vol. 17,1 (1996): 27-33. doi:10.1055/s-2007-972804

BETAINE

  • https://pubmed.ncbi.nlm.nih.gov/22080324/ Trepanowski, John F et al. “The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance trained men.” Journal of strength and conditioning research vol. 25,12 (2011): 3461-71. doi:10.1519/JSC.0b013e318217d48d
  • https://pubmed.ncbi.nlm.nih.gov/21747291/ Hoffman, Jay R et al. “Effect of 15 days of betaine ingestion on concentric and eccentric force outputs during isokinetic exercise.” Journal of strength and conditioning research vol. 25,8 (2011): 2235-41. doi:10.1519/JSC.0b013e3182162530
  • https://pubmed.ncbi.nlm.nih.gov/39514262/ Zawieja, Emilia et al. “Effects of chronic betaine supplementation on exercise performance: Systematic review and meta-analysis.” Journal of sports sciences vol. 42,22 (2024): 2131-2144. doi:10.1080/02640414.2024.2423578
  • https://pubmed.ncbi.nlm.nih.gov/22976217/ Apicella, Jenna M et al. “Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise.” European journal of applied physiology vol. 113,3 (2013): 793-802. doi:10.1007/s00421-012-2492-8
  • https://pubmed.ncbi.nlm.nih.gov/33663545/ Nobari, Hadi et al. “The effects of 14-week betaine supplementation on endocrine markers, body composition and anthropometrics in professional youth soccer players: a double blind, randomized, placebo-controlled trial.” Journal of the International Society of Sports Nutrition vol. 18,1 20. 4 Mar. 2021, doi:10.1186/s12970-021-00417-5
  • https://pubmed.ncbi.nlm.nih.gov/37409757/ Zawieja, Emilia et al. “Betaine supplementation improves CrossFit performance and increases testosterone levels, but has no influence on Wingate power: randomized crossover trial.” Journal of the International Society of Sports Nutrition vol. 20,1 (2023): 2231411. doi:10.1080/15502783.2023.2231411
  • https://pubmed.ncbi.nlm.nih.gov/23967897/ Cholewa, Jason M et al. “Effects of betaine on body composition, performance, and homocysteine thiolactone.” Journal of the International Society of Sports Nutrition vol. 10,1 39. 22 Aug. 2013, doi:10.1186/1550-2783-10-39
  • https://pubmed.ncbi.nlm.nih.gov/36009767/ Yang, Ming-Ta et al. “Effects of 6-Week Betaine Supplementation on Muscular Performance in Male Collegiate Athletes.” Biology vol. 11,8 1140. 29 Jul. 2022, doi:10.3390/biology11081140
  • https://pubmed.ncbi.nlm.nih.gov/19250531/ Hoffman, Jay R et al. “Effect of betaine supplementation on power performance and fatigue.” Journal of the International Society of Sports Nutrition vol. 6 7. 27 Feb. 2009, doi:10.1186/1550-2783-6-7

L-TYROSINE

  • https://pubmed.ncbi.nlm.nih.gov/31771598/ Zaragoza, Javier et al. “Effects of acute caffeine, theanine and tyrosine supplementation on mental and physical performance in athletes.” Journal of the International Society of Sports Nutrition vol. 16,1 56. 26 Nov. 2019, doi:10.1186/s12970-019-0326-3
  • https://pubmed.ncbi.nlm.nih.gov/26424423/ Jongkees, Bryant J et al. “Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review.” Journal of psychiatric research vol. 70 (2015): 50-7. doi:10.1016/j.jpsychires.2015.08.014
  • https://pubmed.ncbi.nlm.nih.gov/27403851/ Colzato, Lorenza S et al. “Effects of l-Tyrosine on working memory and inhibitory control are determined by DRD2 genotypes: A randomized controlled trial.” Cortex vol. 82 (2016): 217-224. doi:10.1016/j.cortex.2016.06.010
  • https://pubmed.ncbi.nlm.nih.gov/25598314/ Steenbergen, Laura et al. “Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance.” Neuropsychologia vol. 69 (2015): 50-5. doi:10.1016/j.neuropsychologia.2015.01.022
  • https://pubmed.ncbi.nlm.nih.gov/10230711/ Deijen, J B et al. “Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course.” Brain research bulletin vol. 48,2 (1999): 203-9. doi:10.1016/s0361-9230(98)00163-4
  • https://pubmed.ncbi.nlm.nih.gov/12887140/ Magill, Richard A et al. “Effects of tyrosine, phentermine, caffeine D-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation.” Nutritional neuroscience vol. 6,4 (2003): 237-46. doi:10.1080/1028415031000120552

GREEN TEA EXTRACT

  • https://pubmed.ncbi.nlm.nih.gov/29746891/ da Silva, Willian et al. “Effect of green tea extract supplementation on exercise-induced delayed onset muscle soreness and muscular damage.” Physiology & behavior vol. 194 (2018): 77-82. doi:10.1016/j.physbeh.2018.05.006
  • https://pubmed.ncbi.nlm.nih.gov/36235549/ Ishikawa, Akira et al. “Effect of Green Tea Extract Ingestion on Fat Oxidation during Exercise in the Menstrual Cycle: A Pilot Study.” Nutrients vol. 14,19 3896. 21 Sep. 2022, doi:10.3390/nu14193896
  • https://pubmed.ncbi.nlm.nih.gov/31747468/ Bagheri, Reza et al. “Does green tea extract enhance the anti-inflammatory effects of exercise on fat loss?.” British journal of clinical pharmacology vol. 86,4 (2020): 753-762. doi:10.1111/bcp.14176
  • https://pubmed.ncbi.nlm.nih.gov/32875933/ Willems, Mark E T et al. “Three Weeks Daily Intake of Matcha Green Tea Powder Affects Substrate Oxidation during Moderate-Intensity Exercise in Females.” Journal of dietary supplements vol. 18,5 (2021): 566-576. doi:10.1080/19390211.2020.1811443
  • https://pubmed.ncbi.nlm.nih.gov/32095935/ Bagheri, Reza et al. “Effects of green tea extract supplementation and endurance training on irisin, pro-inflammatory cytokines, and adiponectin concentrations in overweight middle-aged men.” European journal of applied physiology vol. 120,4 (2020): 915-923. doi:10.1007/s00421-020-04332-6

CDP-CHOLINE

  • https://pubmed.ncbi.nlm.nih.gov/25046515/ Bruce, Steven E et al. “Improvements in concentration, working memory and sustained attention following consumption of a natural citicoline-caffeine beverage.” International journal of food sciences and nutrition vol. 65,8 (2014): 1003-7. doi:10.3109/09637486.2014.940286
  • https://pubmed.ncbi.nlm.nih.gov/21703569/ Arenth, Patricia M et al. “CDP-choline as a biological supplement during neurorecovery: a focused review.” PM & R vol. 3,6 Suppl 1 (2011): S123-31. doi:10.1016/j.pmrj.2011.03.012
  • https://pubmed.ncbi.nlm.nih.gov/25681529/ Knott, Verner et al. “Neurocognitive effects of acute choline supplementation in low, medium and high performer healthy volunteers.” Pharmacology, biochemistry, and behavior vol. 131 (2015): 119-29. doi:10.1016/j.pbb.2015.02.004
  • https://pubmed.ncbi.nlm.nih.gov/8709678/ Secades, J J, and G Frontera. “CDP-choline: pharmacological and clinical review.” Methods and findings in experimental and clinical pharmacology vol. 17 Suppl B (1995): 1-54.
  • https://pubmed.ncbi.nlm.nih.gov/37764658/ Lee, Chang Woock et al. “The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults.” Nutrients vol. 15,18 3874. 6 Sep. 2023, doi:10.3390/nu15183874
  • https://pubmed.ncbi.nlm.nih.gov/34769925/ Gage, Matthew et al. “Choline-Based Multi-Ingredient Supplementation Can Improve Explosive Strength during a Fatiguing Task.” Int J Environ Res Public Health vol. 18,21 11400. 29 Oct. 2021, doi:10.3390/ijerph182111400
  • https://pubmed.ncbi.nlm.nih.gov/26179181/ McGlade, Erin et al. “The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males.” Journal of attention disorders vol. 23,2 (2019): 121-134. doi:10.1177/1087054715593633

CAFFEINE

  • https://pubmed.ncbi.nlm.nih.gov/34033621/ Stadheim, Hans Kristian et al. “Caffeine Increases Exercise Performance, Maximal Oxygen Uptake, and Oxygen Deficit in Elite Male Endurance Athletes.” Medicine and science in sports and exercise vol. 53,11 (2021): 2264-2273. doi:10.1249/MSS.0000000000002704
  • https://pubmed.ncbi.nlm.nih.gov/23573201/ Hodgson, Adrian B et al. “The metabolic and performance effects of caffeine compared to coffee during endurance exercise.” PloS one vol. 8,4 (2013): e59561. doi:10.1371/journal.pone.0059561
  • https://pubmed.ncbi.nlm.nih.gov/31219772/ Chen, Hou-Yu et al. “Effects of caffeine and sex on muscle performance and delayed-onset muscle soreness after exercise-induced muscle damage: a double-blind randomized trial.” Journal of applied physiology vol. 127,3 (2019): 798-805. doi:10.1152/japplphysiol.01108.2018
  • https://pubmed.ncbi.nlm.nih.gov/31492050/ San Juan, Alejandro F et al. “Caffeine Supplementation Improves Anaerobic Performance and Neuromuscular Efficiency and Fatigue in Olympic-Level Boxers.” Nutrients vol. 11,9 2120. 5 Sep. 2019, doi:10.3390/nu11092120
  • https://pubmed.ncbi.nlm.nih.gov/34444656/ Burke, Benjamin I et al. “The Effects of Caffeine on Jumping Performance and Maximal Strength in Female Collegiate Athletes.” Nutrients vol. 13,8 2496. 22 Jul. 2021, doi:10.3390/nu13082496
  • https://pubmed.ncbi.nlm.nih.gov/32681596/ Norum, Martin et al. “Caffeine increases strength and power performance in resistance-trained females during early follicular phase.” Scandinavian journal of medicine & science in sports vol. 30,11 (2020): 2116-2129. doi:10.1111/sms.13776
  • https://pubmed.ncbi.nlm.nih.gov/28537195/ Grgic, Jozo, and Pavle Mikulic. “Caffeine ingestion acutely enhances muscular strength and power but not muscular endurance in resistance-trained men.” European journal of sport science vol. 17,8 (2017): 1029-1036. doi:10.1080/17461391.2017.1330362
  • https://pubmed.ncbi.nlm.nih.gov/17146324/ Beedie, Christopher J et al. “Placebo effects of caffeine on cycling performance.” Medicine and science in sports and exercise vol. 38,12 (2006): 2159-64. doi:10.1249/01.mss.0000233805.56315.a9
  • https://pubmed.ncbi.nlm.nih.gov/37191618/ Grgic, Jozo, and Dorian Varovic. “Moderators of Caffeine's Effects on Jumping Performance in Females: A Systematic Review and Meta-Analysis.” Journal of the American Nutrition Association vol. 43,1 (2024): 92-100. doi:10.1080/27697061.2023.2212740
  • https://pubmed.ncbi.nlm.nih.gov/28603504/ Temple, Jennifer L et al. “The Safety of Ingested Caffeine: A Comprehensive Review.” Frontiers in psychiatry vol. 8 80. 26 May. 2017, doi:10.3389/fpsyt.2017.00080
  • https://pubmed.ncbi.nlm.nih.gov/24530739/ Rivera-Oliver M, Díaz-Ríos M. “Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: a review.” Life Sci. 2014;101(1-2):1-9. doi:10.1016/j.lfs.2014.01.083
  • https://pubmed.ncbi.nlm.nih.gov/19219847/ Addicott MA et al. “The effect of daily caffeine use on cerebral blood flow: How much caffeine can we tolerate?” Hum Brain Mapp. 2009;30(10):3102-14. doi:10.1002/hbm.20732
  • https://pubmed.ncbi.nlm.nih.gov/22561357/ Diukova A et al. “Separating neural and vascular effects of caffeine using simultaneous EEG-fMRI.” Neuroimage. 2012;62(1):239-49. doi:10.1016/j.neuroimage.2012.04.041

POTASSIUM

  • https://pubmed.ncbi.nlm.nih.gov/34112360/ McLean, Rachael Mira, and Nan Xin Wang. “Potassium.” Advances in food and nutrition research vol. 96 (2021): 89-121. doi:10.1016/bs.afnr.2021.02.013
  • https://pubmed.ncbi.nlm.nih.gov/11255136/ Goss, F et al. “Effect of potassium phosphate supplementation on perceptual and physiological responses to maximal graded exercise.” International journal of sport nutrition and exercise metabolism vol. 11,1 (2001): 53-62. doi:10.1123/ijsnem.11.1.53

SODIUM

  • https://pubmed.ncbi.nlm.nih.gov/34579105/ Mente, Andrew et al. “Sodium Intake and Health: What Should We Recommend Based on the Current Evidence?” Nutrients vol. 13,9 3232. 16 Sep. 2021, doi:10.3390/nu13093232
  • https://pubmed.ncbi.nlm.nih.gov/29140136/ Goulet, Eric D B et al. “Salt + Glycerol-Induced Hyperhydration Enhances Fluid Retention More Than Salt- or Glycerol-Induced Hyperhydration.” International journal of sport nutrition and exercise metabolism vol. 28,3 (2018): 246-252. doi:10.1123/ijsnem.2017-0310

L-THEANINE

  • https://pubmed.ncbi.nlm.nih.gov/18681988/ Owen, Gail N et al. “The combined effects of L-theanine and caffeine on cognitive performance and mood.” Nutritional neuroscience vol. 11,4 (2008): 193-8. doi:10.1179/147683008X301513
  • https://pubmed.ncbi.nlm.nih.gov/29420994/ Kahathuduwa, Chanaka N et al. “l-Theanine and caffeine improve target-specific attention to visual stimuli by decreasing mind wandering: a human functional magnetic resonance imaging study.” Nutrition research vol. 49 (2018): 67-78. doi:10.1016/j.nutres.2017.11.002
  • https://pubmed.ncbi.nlm.nih.gov/35565828/ Noah, Lionel et al. “Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals.” Nutrients vol. 14,9 1863. 29 Apr. 2022, doi:10.3390/nu14091863
  • https://pubmed.ncbi.nlm.nih.gov/16930802/ Kimura, Kenta et al. “L-Theanine reduces psychological and physiological stress responses.” Biological psychology vol. 74,1 (2007): 39-45. doi:10.1016/j.biopsycho.2006.06.006
  • https://pubmed.ncbi.nlm.nih.gov/36263942/ Dassanayake, Tharaka L et al. “Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.” Nutritional neuroscience vol. 26,11 (2023): 1138-1146. doi:10.1080/1028415X.2022.2136884
  • https://pubmed.ncbi.nlm.nih.gov/37815006/ Yilmaz, Umut et al. “Effect of single or combined caffeine and L-Theanine supplementation on shooting and cognitive performance in elite curling athletes.” Journal of the International Society of Sports Nutrition vol. 20,1 (2023): 2267536. doi:10.1080/15502783.2023.2267536

MAGNESIUM

  • https://pubmed.ncbi.nlm.nih.gov/28445426/ Boyle NB, Lawton C, Dye L. “The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review.” Nutrients. 2017;9(5):429. doi:10.3390/nu9050429
  • https://pubmed.ncbi.nlm.nih.gov/12160191/ Jee SH et al. “The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials.” Am J Hypertens. 2002;15(8):691-6. doi:10.1016/S0895-7061(02)02964-3
  • https://pubmed.ncbi.nlm.nih.gov/339084/ Robertson D et al. “Effects of caffeine on plasma renin activity, catecholamines and blood pressure.” N Engl J Med. 1978;298(4):181-6. doi:10.1056/NEJM197801262980403
  • https://pubmed.ncbi.nlm.nih.gov/2402180/ Bergman EA et al. “Effects of dietary caffeine on renal handling of minerals in adult women.” Life Sci. 1990;47(6):557-64. doi:10.1016/0024-3205(90)90616-Y

CALCIUM

EGCG (EPIGALLOCATECHIN GALLATE)

  • https://pubmed.ncbi.nlm.nih.gov/17906192/ Boschmann, Michael, and Frank Thielecke. “The effects of epigallocatechin-3-gallate on thermogenesis and fat oxidation in obese men: a pilot study.” Journal of the American College of Nutrition vol. 26,4 (2007): 389S-395S. doi:10.1080/07315724.2007.10719627
  • https://pubmed.ncbi.nlm.nih.gov/20372175/ Thielecke, F et al. “Epigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers: a pilot study.” European journal of clinical nutrition vol. 64,7 (2010): 704-13. doi:10.1038/ejcn.2010.47

VITAMIN C

VITAMIN B1

  • https://pubmed.ncbi.nlm.nih.gov/25566430/ Choi SK et al. “The effects of endurance training and thiamine supplementation on anti-fatigue during exercise.” J Exerc Nutrition Biochem. 2013;17(4):189-98. doi:10.5717/jenb.2013.17.4.189

VITAMIN B2

VITAMIN B6

VITAMIN B11

VITAMIN B12

BLACK PEPPER EXTRACT

  • https://pubmed.ncbi.nlm.nih.gov/24520218/
  • https://pubmed.ncbi.nlm.nih.gov/20492299/ Jin, Ming-Ji, and Hyo-Kyung Han. “Effect of piperine, a major component of black pepper, on the intestinal absorption of fexofenadine and its implication on food-drug interaction.” Journal of food science vol. 75,3 (2010): H93-6. doi:10.1111/j.1750-3841.2010.01542.x
  • https://pubmed.ncbi.nlm.nih.gov/21434835/ Han, Hyo-Kyung. “The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs.” Expert opinion on drug metabolism & toxicology vol. 7,6 (2011): 721-9. doi:10.1517/17425255.2011.570332
  • https://pubmed.ncbi.nlm.nih.gov/23768180/ Butt, Masood Sadiq et al. “Black pepper and health claims: a comprehensive treatise.” Critical reviews in food science and nutrition vol. 53,9 (2013): 875-86. doi:10.1080/10408398.2011.571799
  • https://pubmed.ncbi.nlm.nih.gov/31168845/ Panahi, Yunes et al. “Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial.” Journal of cellular biochemistry vol. 120,9 (2019): 15989-15996. doi:10.1002/jcb.28877
  • https://pubmed.ncbi.nlm.nih.gov/27776366/ Bedada, S K et al. “Effect of Piperine on the Metabolism and Pharmacokinetics of Carbamazepine in Healthy Volunteers.” Drug research vol. 67,1 (2017): 46-51. doi:10.1055/s-0042-118173
  • https://pubmed.ncbi.nlm.nih.gov/36649934/ Hosseini, Hossein et al. “A systematic review and meta-analysis of randomized controlled trials investigating the effect of the curcumin and piperine combination on lipid profile...” Phytotherapy research vol. 37,3 (2023): 1212-1224. doi:10.1002/ptr.7730

HUPERZINE A

  • https://pubmed.ncbi.nlm.nih.gov/18572153/ Haigh, Julian R et al. “Protection of red blood cell acetylcholinesterase by oral huperzine A...” Chemico-biological interactions vol. 175,1-3 (2008): 380-6. doi:10.1016/j.cbi.2008.04.033
  • https://pubmed.ncbi.nlm.nih.gov/10678121/ Sun, Q Q et al. “Huperzine-A capsules enhance memory and learning performance...” Acta pharmacologica Sinica vol. 20,7 (1999): 601-3.
  • https://pubmed.ncbi.nlm.nih.gov/29058298/ Wu, San-Lan et al. “Pharmacokinetics and tolerability of oral dosage forms of huperzine a...” J Huazhong Univ Sci Technolog Med Sci vol. 37,5 (2017): 795-802. doi:10.1007/s11596-017-1807-8
  • https://pubmed.ncbi.nlm.nih.gov/27605862/ Zheng, Wei et al. “Huperzine A for treatment of cognitive impairment in major depressive disorder...” Shanghai archives of psychiatry vol. 28,2 (2016): 64-71. doi:10.11919/j.issn.1002-0829.216003
  • https://pubmed.ncbi.nlm.nih.gov/33182295/ Kaczka, Piotr et al. “Effects of Pre-Workout Multi-Ingredient Supplement on Anaerobic Performance...” Int J Environ Res Public Health vol. 17,21 8262. 9 Nov. 2020, doi:10.3390/ijerph17218262
  • https://pubmed.ncbi.nlm.nih.gov/26962303/ Jagim, Andrew R et al. “The acute effects of multi-ingredient pre-workout ingestion on strength performance...” JISSN vol. 13 11. 8 Mar. 2016, doi:10.1186/s12970-016-0122-2
  • https://pubmed.ncbi.nlm.nih.gov/22941287/ Zhang, Hai-Yan. “New insights into huperzine A for the treatment of Alzheimer's disease.” Acta pharmacologica Sinica vol. 33,9 (2012): 1170-5. doi:10.1038/aps.2012.128
  • https://pubmed.ncbi.nlm.nih.gov/21833673/ Xu, Zhi-Qiang et al. “Treatment with Huperzine A improves cognition in vascular dementia patients.” Cell biochemistry and biophysics vol. 62,1 (2012): 55-8. doi:10.1007/s12013-011-9258-5

On this page, we collect the sources we use to compile our formulas.

These include peer-reviewed studies, systematic reviews, and meta-analyses, supplemented with mechanistic literature where relevant.

We try to base our choices as much as possible on scientific literature that aligns with the formula's purpose.

However, this doesn't mean that every individual ingredient has shown a performance effect in randomized trials, meta-analyses, or systematic reviews, or that we always use the exact same dosages as in those studies.

Dosages can vary, sometimes because studies use different formats, contexts, or target groups.

And possibly because the substantiation is not primarily about a direct "performance outcome," but about a plausible physiological role: for example, as a cofactor, building block, or supporting link in processes relevant to the intended purpose.

Think of this list as our evidence file: you can open, read, and compare every source. If new, convincing data becomes available, we will update the list and adjust our substantiation and choices if this better reflects the state of science.

Do you have a question about a specific study or are you missing a relevant source? Let us know!

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